Our science doesn't plead the fifth
Educational Research Disclaimer. The third-party scientific studies and published citations listed on this page evaluate individual dietary ingredients in isolated research settings. This information is provided solely for educational purposes to explain ingredient selection and formula rationale. These citations do not evaluate the finished NEWBRAIN product and are not intended to represent or imply that this product diagnoses, treats, cures, mitigates, or prevents any disease or medical condition. NEWBRAIN is a dietary supplement formulated to support healthy memory, recall, learning, and a healthy response to everyday stress in healthy adults. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Cognizin® is a studied form of citicoline included to support memory, recall, attention, and mental sharpness. Human research in healthy adults has examined Cognizin® at 250 to 500 mg per day, including a 12-week study using the same 500 mg daily amount found in NEWBRAIN where researchers reported improvements in episodic and overall memory performance in study participants.
How it works: Citicoline supports phospholipid metabolism and phosphatidylcholine production, helping maintain normal brain-cell membranes, signaling, and cognitive function.
Japan and U.S. Cognizin memory research. The Journal of Nutrition.
European citicoline research on memory and cognitive function. EFSA, 2024.
International research history in cognitive support and choline pathways.
Most people know creatine for muscle, but your brain relies on the same ATP energy system. Studies suggest creatine monohydrate can support memory, attention, processing speed, working memory, and cognitive performance when mental demand is high.
That matters most when you are tired, overloaded, or running on less sleep than you should be.
How it works: Creatine supports the phosphocreatine system your brain uses to rapidly regenerate ATP, helping support cellular energy during demanding mental work.
Xu et al., 2024. The Effects of Creatine Supplementation on Cognitive Function in Adults.
Prokopidis et al., 2023. Effects of Creatine Supplementation on Memory in Healthy Individuals.
Rae et al., 2003. Oral Creatine Monohydrate Supplementation Improves Brain Performance.
Human and biochemical research on creatine, phosphocreatine, ATP availability, memory, working memory, and cognitive performance.
Taurine is naturally concentrated in the brain and nervous system and is included in NEWBRAIN to support nervous-system balance, cellular resilience, and normal cognitive function under stress.
Studies suggest taurine plays a role in neural signaling, calcium regulation, antioxidant defense, and mitochondrial function, all of which help support the environment your brain relies on when mental demand rises.
How it works: Taurine acts as an osmolyte and neuromodulator, helping support normal cell signaling, membrane stability, and the regulation of neural excitability.
Chen et al., 2019. Roles of Taurine in Cognitive Function.
Yamori et al., 2009. WHO International Research on Taurine Intake and Healthy Aging.
Japanese and international research on taurine, nervous-system function, cellular protection, and healthy aging.
L-Theanine is included in NEWBRAIN to support stress response, calm alertness, attention, and mental performance under pressure.
Human studies in healthy adults have found benefits in perceived stress, alpha-wave activity, attention, reaction time, verbal fluency, and executive function. NEWBRAIN provides 400 mg per serving, the same daily amount used in a 28-day randomized study that reported lower perceived stress and improved cognitive attention in study participants.
How it works: L-Theanine supports neural activity associated with a relaxed but alert state, helping you stay mentally present without relying on stimulants.
Hidese et al., 2019. L-Theanine and stress measures in healthy adults.
Kimura et al., 2007. L-Theanine Reduces Psychological and Physiological Stress Responses.
Longstanding tea consumption in East Asia, with modern research identifying L-Theanine as a compound associated with calm, alert cognitive states.
Cordyceps militaris is included in NEWBRAIN to support mental stamina, cellular energy, reaction speed, and performance when fatigue starts setting in.
Human studies have reported benefits in oxygen utilization, exercise tolerance, recovery-related markers, and more recently, reaction time after exhaustive exercise.
How it works: Cordyceps militaris contains cordycepin and other bioactive compounds studied for their roles in cellular energy metabolism, oxygen use, and fatigue resistance.
Inoue et al., 2024. Cordyceps militaris in Competitive Long-Distance Runners.
Korea KRIBB, 2011. Cordyceps militaris and Memory-Related Mechanisms.
Thailand, 2024. Cordyceps militaris beverage study in healthy adults.
Uridine is included in NEWBRAIN to support brain-cell membrane formation, synaptic function, learning pathways, and memory support.
Studies suggest UMP supports the structural pathways involved in learning and memory, especially when paired with choline and other phospholipid precursors.
How it works: Uridine feeds into the CDP-choline pathway used to make phosphatidylcholine, one of the major structural components of brain-cell membranes.
Wurtman et al., 2009. Use of Phosphatide Precursors to Promote Synaptogenesis.
Cansev et al., 2005. Oral Uridine-5'-Monophosphate Increases Brain CDP-Choline Levels.
Note: some cited studies examined multinutrient interventions in specific populations. NEWBRAIN is a dietary supplement for healthy adults.
Soininen et al., 2017. 24-month multinutrient intervention study.
Scheltens et al., 2012. Uridine-containing multinutrient, randomized controlled study.
Soininen et al., 2021. 36-month multinutrient follow-up study.
L-Tyrosine is included in NEWBRAIN to support working memory, information processing, cognitive flexibility, and mental performance when stress and mental demand rise.
Human studies suggest tyrosine can help support cognitive performance when demanding conditions begin taxing the systems responsible for working memory and information processing.
How it works: Tyrosine is a precursor used to make dopamine and norepinephrine, neurotransmitters involved in attention, working memory, and adapting to changing demands.
Deijen and Orlebeke, 1994. Effect of Tyrosine on Cognitive Function and Blood Pressure Under Stress.
Colzato et al., 2015. Tyrosine Promotes Cognitive Flexibility During Task Switching.
Hase et al., 2015. Behavioral and Cognitive Effects of Tyrosine Intake in Healthy Human Adults.
Human military and European research on tyrosine, working memory, information processing, and cognitive performance under demanding conditions.
Rhodiola rosea is included in NEWBRAIN to support stress resilience, mental stamina, attention, and cognitive performance when pressure starts wearing you down.
Human studies suggest standardized Rhodiola can support mental performance during stressful conditions, including night work, exam stress, and prolonged fatigue.
How it works: Rhodiola contains rosavins and salidroside, compounds studied for their role in normal stress-response and cellular-adaptation pathways.
Olsson, von Scheele and Panossian, 2009. Rhodiola rosea SHR-5 for Stress-Related Fatigue.
Darbinyan et al., 2000. Rhodiola rosea in Stress-Induced Fatigue During Night Duty.
Spasov et al., 2000. Rhodiola rosea During a Stressful Examination Period.
Kasper and Dienel, 2017. Rhodiola rosea extract in adults reporting prolonged work stress.
Long-standing Russian and Scandinavian use for fatigue, endurance, work capacity, and adaptation to stress.
Lion's Mane is included in NEWBRAIN to support memory, cognitive function, processing speed, and long-term brain health.
Human studies suggest Hericium erinaceus can support cognitive performance, including memory-related measures and speed of performance, while laboratory research has examined compounds in Lion's Mane for their relationship to normal nerve and neuronal function.
How it works: Lion's Mane contains compounds including hericenones and erinacines that are studied for their role in pathways involved in normal nerve signaling and cognitive function.
Mori et al., 2009. Yamabushitake (Hericium erinaceus) and memory measures in older adults.
Saitsu et al., 2019. Improvement of Cognitive Functions by Oral Intake of Hericium erinaceus.
Mori et al., 2008. Hericium erinaceus and cellular signaling activity in laboratory research.
Centuries of culinary and medicinal use in China and Japan.
P-5-P is the active coenzyme form of vitamin B6, included in NEWBRAIN to support normal neurotransmitter production, memory, cognitive function, and nervous-system health.
Human research suggests adequate vitamin B6 status can support memory and cognitive function, while P-5-P plays an essential role in the enzyme pathways used to make several neurotransmitters.
How it works: P-5-P acts as a cofactor in reactions involved in neurotransmitter synthesis and normal nervous-system function.
Long-established biochemical research on P-5-P in neurotransmitter synthesis and normal nervous-system function.
BioPerine® is included in NEWBRAIN to support the absorption and bioavailability of certain nutrients and compounds taken alongside it.
Human research has shown that piperine can increase the bioavailability or bioefficacy of certain co-administered compounds. Other research suggests piperine may also influence intestinal permeability, digestive transit, and metabolic enzymes involved in how compounds are absorbed and broken down.
How it works: Piperine has been studied for its effects on intestinal membrane permeability, gastrointestinal transit, and metabolic pathways that influence absorption and bioavailability. Depending on the compound, this can increase the amount available for the body to use.
Longstanding Ayurvedic use of black pepper in combination formulas intended to support the uptake and effectiveness of other botanical ingredients.
These references were supplied by the licensed vitamin chemist during the formulation of NEWBRAIN. Some are direct human studies, others are mechanism, formulation, or flavor-science references that informed decisions along the way. We list them as they were given to us.
Foundational reference text establishing intake standards for B vitamins and choline. Background authority on nutrient adequacy, not an efficacy study.
Review showing vitamin B6 as a central cofactor in many biochemical reactions. Strong background citation for the role of P-5-P in neurotransmitter-related metabolism.
Randomized controlled study in healthy adults found four weeks of L-Theanine had positive effects on stress measures and cognitive function.
Review of the psychotropic effects of L-Theanine, noting evidence around anti-stress effects, commonly at 200 to 400 mg per day.
Randomized, double-blind, placebo-controlled study of 500 mg citicoline in healthy older adults. One of the strongest direct human citations behind Cognizin.
Pharmacological review of CDP-choline covering safety and mechanisms. Useful background for citicoline.
Found that erinacines from Lion’s Mane mycelia stimulated nerve-related signaling compounds in laboratory testing. A mechanism citation rather than a human study.
Identified erinacine S from Hericium erinaceus. Compound-discovery and mechanistic support rather than direct human cognition evidence.
Systematic review of in-vivo studies on dietary mushrooms and cognition. Broad background rather than proof for a specific dose.
Review concluding that tyrosine appears most useful when dopamine and norepinephrine function is temporarily taxed, such as under stress or demanding conditions.
Animal study showing brain tyrosine concentration can influence norepinephrine synthesis. Mechanistic support rather than a human performance study.
Rat study showing brain tyrosine levels can control striatal dopamine synthesis under certain conditions. Mechanistic, not human cognition evidence.
Randomized controlled study on creatine and cognition. Creatine supports ATP recycling in muscle and brain tissue; findings vary by population and task.
Review of Rhodiola rosea preparations and everyday stress measures. Effects depend heavily on extract type and dose.
Compared sweetened beverages and their effects on post-meal glucose, insulin, and energy intake. Supports the no-added-sugar, naturally sweetened position.
Tested bitter blockers in adults and children. Bitter blocking worked better in adults and depended on the compound and blocker used. Flavor science, not cognition.
Investigated flavanones that reduce activation of the bitter receptor hTAS2R39. Relevant to flavor-masking technology.
We showed you what’s in it, how much is in it, and the research we used to make the decisions. What you do with that information is up to you. Sources include PubMed-indexed research, EFSA, EMA, Nature, Frontiers, MDPI, J-STAGE, and others.
Educational Research Disclaimer. The third-party scientific studies and published citations listed on this page evaluate individual dietary ingredients in isolated research settings. This information is provided solely for educational purposes to explain ingredient selection and formula rationale. These citations do not evaluate the finished NEWBRAIN product and are not intended to represent or imply that this product diagnoses, treats, cures, mitigates, or prevents any disease or medical condition. NEWBRAIN is a dietary supplement formulated to support healthy memory, recall, learning, and a healthy response to everyday stress in healthy adults. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.